研究课题：饮用咖啡与肝硬化患者及死亡率的关系
供稿：公众健康，奥斯陆挪威学会,挪威

    主要内容：目的：研究的目标要评估肝硬化患者饮用咖啡和死亡率之间的关系。
    方法：引入 51,306个为心脏血管的疾病从 1977 到 1983 年死亡率的追踪调查。在这 17 年期间，来自所有的因素死亡的总数是4207。53%的人在死亡证明书上被提到与肝硬化的诊断;这些人中,36%有了酒精导致的肝硬化。结论：肝硬化导致死亡的风险，随着饮咖啡的数量增加，以及性别，年龄，以及饮酒量的不同而变化，而且其主要心脏血管的危险因数是0.6。 (95% 可信度概,0.5-0.8)这与其对酒精性肝硬化结果是同一的。当这种研究深入下去后，我们发现这种反比关系有所增强。
    结论：目前的研究证明了喝咖啡能够降低肝癌的风险。

Coffee intake and mortality from liver cirrhosis.
Tverdal A, Skurtveit S. Ann Epidemiol. 2003 Jul;13(6):419-23.Norwegian Institute of Public Health, Oslo, Norway.
PURPOSE: The aim of the study was to evaluate the association between coffee consumption and mortality from liver cirrhosis. METHODS: We conducted a mortality follow-up of 51,306 adults who underwent screening for cardiovascular disease from 1977 to 1983. During the subsequent 17 years, the total number of deaths from all causes in the studied cohort was 4207. Fifty-three had the diagnosis of cirrhosis mentioned on the death certificate; of these, 36 had alcoholic cirrhosis. RESULTS: The relative risk of liver cirrhosis mentioned on the death certificate associated with an increase of two cups of coffee, adjusted for sex, age, alcohol use and other major cardiovascular risk factors was 0.6 (95% confidence interval, 0.5-0.8). For alcoholic cirrhosis the results were identical. When studying cirrhosis as the underlying cause of death, the inverse relationship becomes somewhat stronger. CONCLUSIONS: The present study confirms the existence of an inverse association between coffee consumption and liver cirrhosis.

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